Methionine aminopeptidase-2 blockade reduces chronic collagen-induced arthritis
Author Information
Author(s): Bainbridge John, Madden Leigh, Essex David, Binks Michael, Malhotra Rajneesh, Paleolog Ewa M
Primary Institution: Kennedy Institute of Rheumatology, Imperial College London
Hypothesis
Can PPI-2458, a selective inhibitor of MetAP-2, reduce the severity of collagen-induced arthritis in mice?
Conclusion
PPI-2458 significantly reduces the severity of arthritis and joint destruction in both acute and chronic models of collagen-induced arthritis.
Supporting Evidence
- PPI-2458 reduced clinical signs of arthritis in both acute and chronic CIA models.
- The reduction in arthritis was associated with decreased joint inflammation and destruction.
- PPI-2458 inhibited human endothelial cell proliferation and angiogenesis in vitro.
Takeaway
This study found that a drug called PPI-2458 can help make sick mice with arthritis feel better by stopping their bodies from making too many new blood vessels.
Methodology
The study used two models of collagen-induced arthritis in mice to assess the effects of PPI-2458 on disease severity and joint destruction.
Participant Demographics
10-week-old male DBA/1 mice were used for acute CIA and 8-week-old male DBA/1 mice for chronic CIA.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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