Omega 3 Fatty Acids and Fluvastatin in Type 2 Diabetes
Author Information
Author(s): Valdivielso Pedro, Rioja José, García-Arias Carlota, Sánchez-Chaparro Miguel Angel, González-Santos Pedro
Primary Institution: Hospital Virgen de la Victoria, Malaga and University of Malaga, Spain
Hypothesis
Does the addition of omega 3 fatty acids to fluvastatin treatment reduce apolipoprotein B48 levels in patients with type 2 diabetes and mixed hyperlipidemia?
Conclusion
The study suggests that adding omega 3 fatty acids to fluvastatin treatment provides additional benefits in reducing atherogenic particles in patients with type 2 diabetes.
Supporting Evidence
- The addition of omega 3 fatty acids led to significant reductions in triglycerides and VLDL triglycerides.
- Fluvastatin alone reduced apolipoprotein B100 by 26%, while the combination with omega 3 enhanced this reduction.
- Apolipoprotein B48 levels only fell significantly after adding omega 3 fatty acids.
Takeaway
This study found that giving omega 3 fatty acids along with a cholesterol medicine helps lower bad fats in people with diabetes.
Methodology
Patients with type 2 diabetes and mixed hyperlipidemia were treated with a low-calorie diet, fluvastatin, and omega 3 fatty acids, with blood samples taken to measure lipid levels.
Potential Biases
Potential bias due to the open-label design and lack of control group.
Limitations
The study had a small sample size and was open-label, which may affect the reliability of the results.
Participant Demographics
Eight patients, five men and three women, aged 57 ± 5 years, all overweight or obese.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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