Genetic Sensitivity to Radiation in Young Head and Neck Cancer Patients
Author Information
Author(s): Papworth R, Slevin N, Roberts S A, Scott D
Primary Institution: Christie Hospital NHS Trust
Hypothesis
Is sensitivity to radiation-induced chromosome damage a marker of genetic predisposition in young head and neck cancer patients?
Conclusion
Some young head and neck cancer patients may have a genetic predisposition indicated by their sensitivity to radiation-induced chromosome damage.
Supporting Evidence
- The mean frequency of radiation-induced G 2 aberrations was higher in patients than in normal controls.
- Younger patients showed significantly more sensitivity to radiation than their age-matched controls.
- There was an inverse correlation between G 2 sensitivity and age for patients.
Takeaway
This study found that some young people with head and neck cancer might be more sensitive to radiation because of their genes.
Methodology
The study compared radiation-induced chromosome damage in patients with head and neck cancer to normal controls using two assays.
Limitations
The study had a small sample size and did not find significant differences in all comparisons.
Participant Demographics
42 patients with head and neck cancer and 27 normal controls, with a focus on those under 45 years old.
Statistical Information
P-Value
0.046
Statistical Significance
p=0.046
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website