Genetic Variants Linked to Alcoholism
Author Information
Author(s): Chen Liang, Liu Nianjun, Wang Shuang, Oh Cheongeun, Carriero Nicholas J, Zhao Hongyu
Primary Institution: Yale University
Hypothesis
Can different genetic markers and phenotypes help identify genetic variants associated with alcoholism?
Conclusion
The study found significant SNPs associated with clinical diagnoses of alcoholism and a significant microsatellite associated with electrophysiological phenotypes.
Supporting Evidence
- 6 significant SNPs were found associated with COGA diagnosis.
- 4 significant SNPs were found associated with DSM-IV diagnosis.
- 1 significant microsatellite was found associated with ERP phenotypes.
Takeaway
Researchers looked at genes to see if they are linked to alcoholism, and they found some important markers that could help us understand the disease better.
Methodology
Family-based association tests (FBAT) and backward haplotype transmission association (BHTA) were used to analyze SNPs and microsatellites in the COGA dataset.
Limitations
The study may not capture all genetic variants due to the complexity of alcoholism and the phenotypes used.
Participant Demographics
1,614 family members, including alcoholic individuals and their relatives.
Statistical Information
Statistical Significance
fdr < 0.1
Digital Object Identifier (DOI)
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