Correlation of MMPs and Their Inhibitors in Breast Cancer
Author Information
Author(s): Figueira Rita CS, Gomes Luciana R, Neto João S, Silva Fabricio C, Silva Ismael DCG, Sogayar Mari C
Primary Institution: Department of Biochemistry, Chemistry Institute, University of São Paulo
Hypothesis
The expression levels of several MMPs and their inhibitors in different models will show a correlation with metastatic potential.
Conclusion
The expression of MMPs and their inhibitors may be regulated by common factors and could provide prognostic information for therapy strategies.
Supporting Evidence
- The study found a significant correlation between MMPs and their inhibitors in both cell lines and tumor samples.
- High levels of MMPs were associated with increased metastatic potential in breast cancer cell lines.
- Expression of MMP inhibitors was modulated by cell-ECM interactions in highly invasive cell lines.
- Results suggest that MMPs and their inhibitors may be regulated by common signaling pathways.
Takeaway
This study looks at how certain proteins related to cancer spread are connected in breast cancer tissues and cell lines, suggesting they might work together.
Methodology
The study analyzed expression levels of MMPs and their inhibitors using quantitative RT-PCR in breast cancer cell lines and tissue samples.
Limitations
The study may not account for all factors influencing MMP and inhibitor expression in a clinical setting.
Participant Demographics
72 primary breast tumors and 30 adjacent normal tissues from patients.
Statistical Information
P-Value
p < 0.001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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