Low-dose retinoic acid enhances in vitro invasiveness of human oral squamous-cell-carcinoma cell lines
2001
Low-dose retinoic acid and oral cancer cell invasiveness
publication
Author Information
Author(s): Uchida D, Kawamata H, Nakashiro K, Omotehara F, Hino S, Hoque M O, Begum N-M, Yoshida H, Sato M, Fujimori T
Primary Institution: Tokushima University School of Dentistry
Hypothesis
Low-dose retinoic acids enhance the invasiveness of oral squamous cell carcinoma cells.
Conclusion
Low-dose retinoic acids increase the invasiveness of oral squamous cell carcinoma cells by activating certain proteins.
Supporting Evidence
- Low-dose retinoic acids enhanced the activity of tissue-type plasminogen activator.
- Low-dose retinoic acids activated pro-matrix metalloproteinases.
- Activation of proMMP2 and proMMP9 was inhibited by aprotinin.
Takeaway
This study found that small amounts of retinoic acid can make certain cancer cells more aggressive.
Methodology
The study examined the effects of retinoic acids on the invasive potentials of oral squamous cell carcinoma cell lines in vitro.
Digital Object Identifier (DOI)
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