Complex Genomic Imprinting Patterns in Mice
Author Information
Author(s): Wolf Jason B., Cheverud James M., Roseman Charles, Hager Reinmar
Primary Institution: University of Manchester
Hypothesis
What is the contribution of genomic imprinting to quantitative variation in complex traits in mice?
Conclusion
The study identified ten imprinted quantitative trait loci (iQTL) that display complex and diverse effect patterns, suggesting that imprinting effects can vary over time and may be stronger later in life.
Supporting Evidence
- Ten loci were identified that show significant parent-of-origin dependent effects.
- Four loci displayed effects similar to the callipyge mutation found in sheep.
- Most imprinting effects were strongest during the post-weaning period.
Takeaway
Some genes only work if they come from your mom or dad, and this study found that these genes can affect how big mice grow in different ways as they get older.
Methodology
The study used a genome-wide scan for imprinted quantitative trait loci (iQTL) affecting body weight and growth in mice using a three-generation design.
Potential Biases
Potential bias due to the limited genetic diversity of the inbred mouse strains used.
Limitations
The study primarily focused on specific traits and may not generalize to all traits affected by genomic imprinting.
Participant Demographics
The study involved F2 and F3 generations of an intercross between two inbred mouse strains, LG/J and SM/J.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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