Vitamin A and Lung Cancer: A Systematic Review and Meta Analysis
Author Information
Author(s): Fritz Heidi, Kennedy Deborah, Fergusson Dean, Fernandes Rochelle, Doucette Steve, Cooley Kieran, Seely Andrew, Sagar Stephen, Wong Raimond, Seely Dugald
Primary Institution: The Canadian College of Naturopathic Medicine
Hypothesis
Is vitamin A effective for the treatment and prevention of lung cancers?
Conclusion
There is a lack of evidence to support the use of naturally occurring retinoids for the treatment and prevention of lung cancers.
Supporting Evidence
- 248 studies were included for full review and analysis.
- Five RCTs assessed treatment of lung cancers.
- Three studies on secondary prevention revealed no significant effects on mortality.
- Retinyl palmitate combined with beta carotene increased risk of lung cancer in smokers.
- Pooling of studies showed no significant effects on response rate or survival.
Takeaway
This study looked at whether vitamin A helps with lung cancer, but found that it doesn't really work.
Methodology
The authors conducted a systematic review and meta-analysis of clinical, observational, and preclinical studies on vitamin A and lung cancer.
Potential Biases
Potential biases include publication bias and the variability in study designs and populations.
Limitations
The study included a wide range of evidence, but many trials had inconsistent results and some were not well-designed.
Participant Demographics
The studies included various populations, including smokers and patients with different types of lung cancer.
Statistical Information
P-Value
p<0.014
Confidence Interval
95% CI 1.13–1.35
Statistical Significance
p<0.014
Digital Object Identifier (DOI)
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