Spatial Analysis of BSE Cases in the Netherlands
Author Information
Author(s): Heres Lourens, Brus Dick J, Hagenaars Thomas J
Primary Institution: Central Veterinary Institute of Wageningen UR
Hypothesis
Is there spatial clustering present in the Dutch BSE epidemic?
Conclusion
Significant spatial case clustering is present in the Dutch BSE epidemic, likely due to time-dependent heterogeneities in exposure related to feed production.
Supporting Evidence
- Three spatial case clusters were identified in the Dutch BSE epidemic.
- Stronger spatial clustering was observed when using a cohort-based analysis.
- Most BSE infections occur in animals less than 12 or 18 months old.
Takeaway
The study found that BSE cases in the Netherlands are not randomly spread out; instead, they tend to cluster in certain areas, which might be linked to how cattle were fed.
Methodology
The study analyzed BSE cases from 2001 to 2004 using spatial clustering tests, including Diggle and Chetwynd's method and the Kulldorff scan test.
Potential Biases
Potential bias due to regional differences in disease surveillance intensity and feed production practices.
Limitations
Insufficient data prevented a detailed explanation of the underlying mechanisms for the observed clustering.
Participant Demographics
Cattle from Dutch dairy farms, with a focus on those older than 2 years.
Statistical Information
P-Value
0.001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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