Retinal Glia in Myopia: Current Understanding and Future Directions
Author Information
Author(s): Chen Pengfan, Ji Jing, Chen Xinyi, Zhang Jiali, Wen Xiangyi, Liu Longqian
Primary Institution: West China Hospital, Sichuan University, Chengdu, Sichuan, China
Hypothesis
How the various populations of glia in the retina are involved in myopia is unclear.
Conclusion
This review assesses current knowledge about how myopia may involve retinal glia and explores directions for future research.
Supporting Evidence
- The prevalence of myopia is expected to affect nearly half the global population by 2050.
- Myopia is one of the most frequent causes of visual impairment.
- Astrogliosis in myopia may influence blood oxygen supply and neuronal function.
- Müller cells may act as sensors of mechanical stretching in myopia.
- Microglia may exhibit a reactive morphology and elevated response to inflammation in myopia.
Takeaway
Myopia is a condition that affects vision, and this study looks at how different types of cells in the retina, called glia, might be involved in causing it.
Methodology
This is a review article summarizing existing research on retinal glia and their potential roles in myopia.
Limitations
Direct evidence linking astrogliosis to myopia in humans is lacking.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website