Endothelin 1 Levels and Henoch Schonlein Purpura
Author Information
Author(s): Fessatou S, Nicolaidou P, Gourgiotis D, Georgouli H, Douros K, Moustaki M, Fretzayas A
Primary Institution: 3rd Department of Pediatrics 'Attikon' University Hospital, Athens University School of Medicine, Athens, Greece
Hypothesis
Are ET-1 levels correlated with the clinical presentation and outcome of Henoch Schonlein purpura?
Conclusion
Urinary ET-1 levels are a useful marker for the duration of the acute phase of HSP but not for the length of renal involvement.
Supporting Evidence
- ET-1 levels in plasma and urine did not differ between patients and controls at three distinct time points.
- The urinary ET-1 levels were a significant predictor of the duration of the acute phase of HSP.
- Renal involvement was independent from the ET-1 measurements.
Takeaway
This study looked at a substance called ET-1 in kids with a condition called Henoch Schonlein purpura. It found that ET-1 in urine can help show how long the sickness lasts.
Methodology
The study involved 30 patients with HSP and an equal number of healthy controls, measuring ET-1 levels in blood and urine at three time points.
Limitations
The study did not find differences in ET-1 levels between patients and controls, and the correlation with renal involvement was not established.
Participant Demographics
Patients aged 2–12.6 years, with a male to female ratio of 14/16.
Statistical Information
P-Value
0.032
Confidence Interval
0.96–0.99
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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