Decreased expression of p57KIP2mRNA in human bladder cancer
2000
Decreased p57KIP2 mRNA in Bladder Cancer
Sample size: 24
publication
Author Information
Author(s): Oya M, Schulz W A
Primary Institution: Urologische Klinik, Heinrich Heine Universität
Hypothesis
The study aims to identify genetic and epigenetic alterations on chromosome 11p15.5 in human bladder cancer.
Conclusion
The KIP2 gene is frequently altered in bladder cancer, with decreased expression observed in many tumor samples.
Supporting Evidence
- Decreased expression of KIP2 was identified in 37% of tumor specimens.
- Decreased IGF2 and H19 mRNA levels were found in 21% and 13% of tumors, respectively.
- Almost all bladder carcinoma cell lines showed significant changes in gene expression.
Takeaway
Researchers looked at bladder cancer samples and found that a gene called KIP2 was often not working properly, which might help us understand the disease better.
Methodology
Quantitative RT-PCR was used to study gene expression in paired samples of urothelial carcinomas and normal mucosa.
Digital Object Identifier (DOI)
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