Chromosome 1p and 11q Deletions and Outcome in Neuroblastoma—A Critical Review
2008
Chromosome 1p and 11q Deletions in Neuroblastoma
Sample size: 915
publication
Evidence: moderate
Author Information
Author(s): Komotar Ricardo J., Otten Marc L., Starke Robert M., Anderson Richard C. E.
Primary Institution: Columbia University
Hypothesis
11q23 LOH could be a useful prognostic marker in neuroblastoma.
Conclusion
1p36 and unb11q LOH are risk factors that should be incorporated into clinical trials of neuroblastoma.
Supporting Evidence
- Patients with 1p36 LOH had lower three-year event-free and overall survival rates compared to those without it.
- Unbalanced 11q LOH was strongly associated with decreased event-free and overall survival.
- Patients without MYCN amplification showed significant associations with 1p36 LOH and unb11q LOH.
Takeaway
This study found that certain genetic changes in neuroblastoma can help doctors predict how well a patient will do and tailor treatments better.
Methodology
The study screened 915 neuroblastoma samples for LOH at chromosome bands 1p36 and 11q23 and analyzed associations with survival.
Limitations
The study is somewhat limited by the small numbers within subgroups.
Statistical Information
P-Value
<0.001
Statistical Significance
p<0.001
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