CD9P-1 and Lung Cancer Metastasis
Author Information
Author(s): Guilmain W, Colin S, Legrand E, Vannier J P, Steverlynck C, Bongaerts M, Vasse M, Al-Mahmood S
Primary Institution: Gene Signal Research Center
Hypothesis
CD9P-1 expression correlates with the metastatic status of lung cancer.
Conclusion
CD9P-1 expression is positively correlated with the metastatic status of lung tumors, and its upregulation may contribute to the loss of CD9 in solid tumors.
Supporting Evidence
- Loss of CD9 is inversely related to the expression of CD9P-1.
- GS-168AT2 treatment led to a drastic inhibition of tumor growth in mice.
- CD9P-1 expression was found to be higher in metastatic tumors compared to non-metastatic ones.
Takeaway
This study found that a protein called CD9P-1 is linked to how much lung cancer spreads, and a special version of this protein can help slow down tumor growth.
Methodology
The study involved measuring CD9 and CD9P-1 expression in human lung tumors and testing the effects of GS-168AT2 on tumor growth in mice.
Participant Demographics
The study included 55 human lung tumor biopsies.
Statistical Information
P-Value
0.0003
Confidence Interval
95% CI=−1.938 to −0.6739
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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