(1S,2S,3R,4S,5R,7S,8S,10R,13S)-2-Debenzoyl-10-deacetyl-2-(3-fluorobenzoyl)-7,10-bis(2,2,2-trichloroethoxycarbonyl)baccatin III ethyl acetate monosolvate monohydrate
2011
Synthesis and Structure of a Fluorinated Docetaxel Analog
publication
Evidence: high
Author Information
Author(s): Zhang Chen, Xie Cheng, Chang Jun, Lu Hong-Fu, Sun Xun
Primary Institution: Fudan University
Hypothesis
The study aims to determine the absolute configurations of a novel fluorinated docetaxel analog.
Conclusion
The absolute configurations for the nine chiral centers of the molecule were successfully determined.
Supporting Evidence
- The absolute configurations for the nine chiral centers were determined.
- The compound was obtained with a 94% yield.
- Hydrogen bonds were identified in the crystal structure.
Takeaway
The researchers made a new compound related to cancer treatment and figured out how its atoms are arranged.
Methodology
The compound was synthesized through a series of chemical reactions and characterized using X-ray crystallography.
Digital Object Identifier (DOI)
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