Altered expression of the IGF-1 receptor in a tamoxifen-resistant human breast cancer cell line
1999
IGF-1 Receptor Changes in Tamoxifen-Resistant Breast Cancer Cells
publication
Author Information
Author(s): Parisot J P, Hu X F, DeLuise M, Zalcberg J R
Primary Institution: Peter MacCallum Cancer Institute
Hypothesis
The study investigates the relationship between oestrogen and IGF-1 in tamoxifen-sensitive and tamoxifen-resistant breast cancer cell lines.
Conclusion
The study found that oestrogen may make tamoxifen-resistant breast cancer cells more responsive to growth signals from IGF-2.
Supporting Evidence
- E2 stimulated the growth of both tamoxifen-sensitive and resistant cells significantly.
- Only the tamoxifen-resistant cells showed a significant response to IGF-1.
- A combination of E2 and IGF-1 greatly enhanced cell growth in both cell lines.
Takeaway
This study shows that a hormone called oestrogen can help certain breast cancer cells grow even when they resist a common treatment called tamoxifen.
Methodology
The study examined the growth of tamoxifen-sensitive and resistant breast cancer cell lines in serum-free medium with different treatments over 7 days.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website