Impact of Menstrual Cycle and Menopause on Breast Cancer Protein Levels
Author Information
Author(s): Pujol P, Daurès J-P, Brouillet J-P, Maudelonde T, Rochefort H, Grenier J
Primary Institution: Centre Hospitalier Universitaire de Montpellier-Nîmes
Hypothesis
How do the menstrual cycle phase and menopausal status affect pS2 and cathepsin D levels in breast cancer?
Conclusion
The study found that pS2 levels vary with menstrual cycle phase and menopausal status, while cathepsin D levels do not.
Supporting Evidence
- pS2 levels were higher in the follicular phase compared to the luteal phase.
- Menopausal patients had lower pS2 levels than women in the menstrual cycle.
- No differences in cathepsin D levels were observed across menstrual phases or menopausal status.
Takeaway
This study looked at how the time of surgery during a woman's menstrual cycle or menopause affects certain proteins related to breast cancer. It found that one protein, pS2, changes with these factors, but another protein, cathepsin D, does not.
Methodology
The study measured tumoral levels of pS2 and cathepsin D in a population of breast cancer patients and analyzed hormonal levels at the time of surgery.
Participant Demographics
The study included 1750 patients with breast cancer, of which 339 were in the menstrual cycle phase.
Statistical Information
P-Value
0.0001
Statistical Significance
p=0.0001
Digital Object Identifier (DOI)
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