Bone marrow changes in multiple myeloma
Author Information
Author(s): Ribatti D, Vacca A, Nico B, Quondamatteo F, Ria R, Minischetti M, Marzullo A, Herken R, Roncali L, Dammacco F
Primary Institution: University of Bari Medical School
Hypothesis
Angiogenesis parallels progression of multiple myeloma, and mast cells participate in its induction via angiogenic factors in their secretory granules.
Conclusion
The study found increased angiogenesis and mast cell density in the bone marrow of patients with active multiple myeloma compared to those with non-active disease and monoclonal gammopathy.
Supporting Evidence
- The study analyzed bone marrow samples from 80 patients.
- Active multiple myeloma patients showed increased angiogenesis.
- Mast cell density was higher in patients with active disease.
Takeaway
In patients with multiple myeloma, the bone marrow shows more blood vessel growth and more mast cells as the disease gets worse.
Methodology
Immunohistochemical, cytochemical, and ultrastructural analysis of bone marrow samples from patients.
Participant Demographics
24 patients with active multiple myeloma, 34 patients with non-active multiple myeloma, and 22 patients with monoclonal gammopathy of undetermined significance.
Digital Object Identifier (DOI)
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