Profound gastric mucosal changes and severe rebound acid hypersecretion after long‐term Vonoprazan use: A case report
2024
Gastric Changes After Long-Term Use of Vonoprazan
Sample size: 1
publication
Evidence: low
Author Information
Author(s): Suda Hiroko, Eto Sachi, Sakurai Koichi
Primary Institution: Hattori Clinic, Kumamoto, Japan
Hypothesis
What are the effects of long-term Vonoprazan use on gastric mucosa?
Conclusion
Long-term use of Vonoprazan can lead to significant gastric mucosal changes and severe rebound acid hypersecretion after discontinuation.
Supporting Evidence
- Vonoprazan is more potent than proton pump inhibitors.
- The patient developed gastric polyps after switching to Vonoprazan.
- Significant gastric mucosal changes were observed after long-term use.
- Rebound acid hypersecretion occurred after discontinuing Vonoprazan.
- Histological analysis showed parietal cell and G-cell hyperplasia.
Takeaway
Taking Vonoprazan for a long time can change your stomach lining and cause problems when you stop taking it.
Methodology
Case report of a 76-year-old man who used Vonoprazan for 6 years and experienced gastric changes and complications.
Limitations
Only one case is reported, limiting generalizability.
Participant Demographics
76-year-old male with a history of hypertension and previous proton pump inhibitor use.
Digital Object Identifier (DOI)
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