Antibody BNH9 Detects Red Blood Cell Antigens in Lymphomas
Author Information
Author(s): G. Delsoll, A. Blancher, T. Al Saatil, E. Ralfkiaer, A. Lauritzen, L. Bruigeres, P. Brousset, F. Rigal-Huguet, C. Mazerolles, A. Robert, S.M. Chittal
Primary Institution: CHU Purpan, Toulouse, France
Hypothesis
The study investigates the reactivity of monoclonal antibodies BNH9 and BNF13 with lymphoid neoplasms, particularly anaplastic large cell lymphomas.
Conclusion
The BNH9 antibody shows strong reactivity with H and Y antigens in 51% of anaplastic large cell lymphomas, indicating biological differences from other lymphomas.
Supporting Evidence
- BNH9 reacted with 51% of anaplastic large cell lymphomas.
- Only 5.7% of other non-Hodgkin's lymphomas were positive for BNH9.
- Strong expression of H and/or Y antigens was observed in ALC lymphomas.
- Children had a higher positivity rate for BNH9 compared to adults.
Takeaway
Researchers created antibodies to find specific markers in certain cancers, and they found that one of these antibodies works well on a type of lymphoma.
Methodology
Monoclonal antibodies BNH9 and BNF13 were generated and tested on various lymphoid neoplasms and normal tissues using immunohistochemistry.
Limitations
The study primarily focused on paraffin-embedded tissues, which may limit the detection of certain antigens.
Participant Demographics
Included cases of anaplastic large cell lymphomas, non-Hodgkin's lymphomas, and Hodgkin's disease.
Statistical Information
P-Value
0.0023
Statistical Significance
p=0.0023
Want to read the original?
Access the complete publication on the publisher's website