Plant-Made Trastuzumab Inhibits Cancer Cell Growth
Author Information
Author(s): Komarova Tatiana V., Kosorukov Vyacheslav S., Frolova Olga Y., Petrunia Igor V., Skrypnik Ksenia A., Gleba Yuri Y., Dorokhov Yuri L.
Primary Institution: A.N. Belozersky Institute of Physico-Chemical Biology, Moscow State University
Hypothesis
Can trastuzumab produced in plants effectively inhibit cancer cell proliferation and tumor growth?
Conclusion
Plant-made trastuzumab is effective in suppressing cancer cell proliferation and tumor growth.
Supporting Evidence
- Plant-made trastuzumab bound to HER2/neu oncoprotein and inhibited SK-BR-3 cell proliferation.
- In vivo studies showed that PMT administration retarded tumor growth in a mouse model.
- The study demonstrated that PMT had similar effects to the commercially available trastuzumab.
Takeaway
Scientists made a cancer-fighting medicine from plants, and it worked well to stop cancer cells from growing.
Methodology
The study used an Agrobacterium-mediated transient expression system to produce trastuzumab in Nicotiana benthamiana plants and tested its effects on cancer cell lines and in a mouse model.
Limitations
The study does not fully establish that plant-made trastuzumab is biosimilar to the original trastuzumab.
Participant Demographics
The study involved human cancer cell lines and a mouse model.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website