AIP4/Itch Regulates Notch Receptor Degradation in the Absence of Ligand
2008
How Itch Regulates Notch Receptor Degradation
publication
Evidence: moderate
Author Information
Author(s): Chastagner Patricia, Israël Alain, Brou Christel
Primary Institution: Institut Pasteur, Paris, France
Hypothesis
Itch/AIP4 is necessary for the degradation of the Notch receptor in the absence of ligand.
Conclusion
The study identifies a specific step in Notch regulation that is dependent on Itch/AIP4 for receptor degradation.
Supporting Evidence
- Itch is required for the degradation of Notch in the absence of ligand.
- Itch catalyzes Notch polyubiquitination through K29-linked chains.
- Notch degradation is delayed in Itch-/- cells.
Takeaway
Itch helps control how much Notch is available in cells by making sure it gets broken down when not needed.
Methodology
The study used Itch-/- fibroblasts expressing the Notch1 receptor to analyze the role of Itch in Notch degradation.
Digital Object Identifier (DOI)
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