Improving Antimicrobial and Antiviral Activities with Natterins-based Peptides
Author Information
Author(s): de Cena Gabrielle L., Tada Dayane B., Lucchi Danilo B.M., Santos Tiago A.A., Heras Montserrat, Juliano Maria, Torres Braconi Carla, Castanho Miguel A.R.B., Lopes-Ferreira Mônica, Conceição Katia
Primary Institution: Universidade Federal de São Paulo (UNIFESP)
Hypothesis
Can peptides derived from Natterins improve antimicrobial and antiviral activities?
Conclusion
The study found that Natterins-based peptides demonstrated significant antimicrobial efficacy and low cytotoxicity, although their antiviral efficacy was limited.
Supporting Evidence
- The peptides showed significant antimicrobial efficacy against Pseudomonas aeruginosa, Staphylococcus aureus, and Candida auris.
- The peptides exhibited low cytotoxicity in murine fibroblast cells.
- Stability tests indicated that the peptides remained stable under various temperatures and pH conditions.
- The in vivo toxicity tests in Galleria mellonella indicated a favorable safety profile.
Takeaway
Scientists created special peptides from fish venom that can fight germs and viruses, but they work better against germs than viruses.
Methodology
The peptides were synthesized and tested for stability, antimicrobial activity against various bacteria and fungi, cytotoxicity in murine fibroblast cells, and antiviral activity against the Chikungunya virus.
Limitations
The antiviral efficacy of the peptides was limited, and their effectiveness decreased over time.
Statistical Information
P-Value
p<0.0001
Statistical Significance
p<0.0001
Digital Object Identifier (DOI)
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