Sequence variations in DNA repair gene XPC is associated with lung cancer risk in a Chinese population: a case-control study

2007

DNA Repair Gene Variations and Lung Cancer Risk in China

Sample size: 2021 publication 10 minutes Evidence: moderate

Author Information

Author(s): Bai Yun, Xu Liang, Yang Xiaobo, Hu Zhibin, Yuan Jing, Wang Feng, Shao Minhua, Yuan Wentao, Qian Ji, Ma Hongxia, Wang Ying, Liu Hongliang, Chen Weihong, Yang Lin, Jing Guangfu, Huo Xiang, Chen Feng, Liu Yanhong, Jin Li, Wei Qingyi, Huang Wei, Shen Hongbing, Lu Daru, Wu Tangchun

Primary Institution: Institute of Occupational Medicine and Ministry of Education Key Lab for Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology

Hypothesis

Inherited sequence variations in XPC may alter DNA repair and thus susceptibility to cancer.

Conclusion

Inherited sequence variations in XPC may modulate risk of lung cancer, especially lung adenocarcinoma, in Chinese populations.

Supporting Evidence

The study found that the rs3731055 AG+AA variant genotypes were associated with a decreased risk of lung adenocarcinoma.
The haplotype ACCCA was associated with a decreased risk of lung adenocarcinoma but an increased risk of small cell carcinomas.
The protective effect of rs3731055AG+AA was more evident among young subjects and never smokers.

Takeaway

Some people have changes in their DNA that can make them more or less likely to get lung cancer. This study looked at a group of Chinese people to see how these changes affect their risk.