Bone Loss and New Bone Formation in Ankylosing Spondylitis
Author Information
Author(s): Korkosz Mariusz, Gąsowski Jerzy, Grzanka Piotr, Gorczowski Janusz, Pluskiewicz Wojciech, Jeka Sławomir, Grodzicki Tomasz
Primary Institution: Jagiellonian University
Hypothesis
Does baseline new bone formation predict bone loss in ankylosing spondylitis over a 10-year period?
Conclusion
In ankylosing spondylitis patients not using antiosteoporotic therapy, spine trabecular bone density decreased over 10 years and was not related to baseline radiological severity.
Supporting Evidence
- Bone mineral content decreased significantly over 10 years as measured by QCT.
- Baseline radiological severity did not predict the progression of bone loss.
- Patients with advanced radiological scores had lower bone mineral content at both baseline and follow-up.
Takeaway
This study found that in people with a certain type of back disease, the amount of bone loss over 10 years didn't depend on how much new bone had formed at the start.
Methodology
Fifteen ankylosing spondylitis patients underwent X-ray, DXA, and QCT measurements at baseline and after 10 years.
Potential Biases
The influence of NSAIDs on syndesmophyte growth and the difficulty in separating disease effects from aging may introduce bias.
Limitations
The sample size was relatively low, which limited the statistical analysis and the ability to control for confounding factors.
Participant Demographics
The study included 15 male patients with a mean age of 45.6 years and an average disease duration of 16.5 years.
Statistical Information
P-Value
p = 0.001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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