E-cadherin mutations in gastric cancer
Author Information
Author(s): Stone J, Bevan S, Cunningham D, Hill A, Rahman N, Peto J, Marossy A, Houlston R S
Primary Institution: Section of Cancer Genetics, Institute of Cancer Research
Hypothesis
Germline mutations in the E-cadherin gene contribute to the development of gastric cancer.
Conclusion
Germline mutations in E-cadherin do not account for more than 3% of gastric cancers.
Supporting Evidence
- No pathogenic mutations were observed in any of the 106 patients.
- The results indicate that germline mutations in E-cadherin will not account for more than 3% of gastric cancers.
Takeaway
Scientists looked for changes in a gene called E-cadherin in people with stomach cancer and found that these changes are not common.
Methodology
The study examined the E-cadherin gene for mutations in 106 gastric cancer patients, including 10 with a family history and 96 sporadic cases.
Participant Demographics
106 gastric cancer patients, 10 with a family history and 96 sporadic cases.
Digital Object Identifier (DOI)
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