Golden Mushroom Polysaccharides Help Treat Colitis in Mice
Author Information
Author(s): Alioui Yamina, Ullah Hidayat, Ali Sharafat, Rahman Mujeeb Ur, Elkharti Maroua, Farooqui Nabeel Ahmed, Rehman Ata Ur, Ilyas Muhammad, Alsholi Duaa M., Siddiqi Nimra Zafar, Ali Muhsin, Wang Liang, Xin Yi
Primary Institution: Dalian Medical University, Dalian, China
Hypothesis
Cantharellus cibarius Fr. derived polysaccharides could alleviate ulcerative colitis by modulating gut microbiota and restoring intestinal homeostasis.
Conclusion
The study found that polysaccharides from the golden chanterelle mushroom can significantly alleviate symptoms of colitis in mice by restoring intestinal barrier integrity and modulating gut microbiota.
Supporting Evidence
- CCP treatment improved body weight and intestinal integrity in mice.
- CCP administration regulated immune responses by affecting cytokine levels.
- 16S rRNA sequencing showed that CCP modulated gut dysbiosis.
Takeaway
Researchers found that a mushroom extract can help mice with a gut problem by making their intestines healthier and helping the good bacteria grow.
Methodology
BALB/c mice were given DSS to induce colitis and then treated with crude polysaccharide extract from C. cibarius for 14 days, with various assessments including histological analysis and cytokine levels.
Participant Demographics
Male BALB/c mice, aged 4-5 weeks.
Statistical Information
P-Value
p<0.01
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website