Agaricus blazei Extract Induces Apoptosis in Leukemic Cells
Author Information
Author(s): Kim Mun-Ock, Moon Dong-Oh, Jung Jin Myung, Lee Won Sup, Choi Yung Hyun, Kim Gi-Young
Primary Institution: Jeju National University
Hypothesis
Does Agaricus blazei extract exert antiproliferative and apoptotic effects in human leukemic THP-1 cells?
Conclusion
Agaricus blazei extract induces apoptosis in THP-1 cells through ROS-dependent JNK activation and inhibition of NF-κB.
Supporting Evidence
- ABE treatment resulted in a dose-dependent inhibition of viability in THP-1 cells.
- ABE caused significant increases in apoptotic cell percentages compared to control cells.
- ABE treatment led to the accumulation of cytochrome c in the cytoplasm and increased caspase activity.
- ABE suppressed constitutive NF-κB activation and NF-κB-regulated gene products.
Takeaway
Agaricus blazei, a type of mushroom, can help kill cancer cells by making them produce harmful substances that lead to cell death.
Methodology
The study involved treating THP-1 cells with Agaricus blazei extract and analyzing cell viability, apoptosis, and related molecular pathways.
Participant Demographics
Human leukemic THP-1 cells were used in the study.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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