The Role of pH Fronts in Reversible Electroporation
Author Information
Author(s): Turjanski Pablo, Olaiz Nahuel, Maglietti Felipe, Michinski Sebastian, Suárez Cecilia, Molina Fernando Victor, Marshall Guillermo
Primary Institution: Universidad de Buenos Aires, Buenos Aires, Argentina
Hypothesis
The study investigates the role of pH fronts in ion transport during reversible electroporation.
Conclusion
The study found that pH fronts are immediate and substantial during reversible electroporation, which could lead to tissue necrosis.
Supporting Evidence
- The study revealed significant pH gradients during electroporation.
- Anodic acidification was found to be larger in ECT than in EChT.
- The pH fronts scale in time as characteristic of a predominantly diffusive process.
Takeaway
When using electric pulses to treat tumors, the pH levels change a lot, which can harm the tissue. This study helps us understand how to make this treatment safer.
Methodology
The study used experimental measurements and theoretical modeling to analyze ion transport in agar gels during reversible electroporation.
Digital Object Identifier (DOI)
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