Optimizing Oral Drug Delivery of Ornidazole
Author Information
Author(s): Asane Govind S., Rao Yamsani Madhusudan, Bhatt Jaykrishna H., Shaikh Karimunnisa S.
Primary Institution: Pravara Rural College of Pharmacy
Hypothesis
Can mucoadhesive oral multiple unit systems (MUS) sustain the release of ornidazole in the gastrointestinal tract?
Conclusion
The study found that the MUS can effectively deliver ornidazole with improved pharmacokinetic parameters compared to immediate release tablets.
Supporting Evidence
- The MUS showed a retention time in the gastrointestinal tract for more than 5 hours.
- The entrapment efficiency of the MUS ranged from 80% to 96%.
- The pharmacokinetic parameters of the MUS were significantly improved compared to marketed immediate release tablets.
Takeaway
This study shows a new way to deliver a medicine called ornidazole that helps it stay in your tummy longer, which can make it work better.
Methodology
The MUS were prepared using ionotropic gelation method and evaluated in vitro and in vivo for their drug release and pharmacokinetic properties.
Potential Biases
Potential bias in the selection of volunteers and the crossover design of the study.
Limitations
The study was limited to a small sample size and specific conditions that may not represent broader populations.
Participant Demographics
Eight healthy male volunteers aged 25-30 years, weighing 60-65 kg.
Statistical Information
P-Value
p<0.0001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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