Aptamin C and Its Effects on Pulmonary Fibrosis
Author Information
Author(s): Shin Seulgi, Jo Hyejung, Agura Tomoyo, Jeong Seoyoun, Ahn Hyovin, Pang Soyoung, Lee June, Park Jeong-Ho, Kim Yejin, Kang Jae Seung, Ruaro Barbara
Primary Institution: Seoul National University College of Medicine
Hypothesis
Can Aptamin C inhibit the progression of pulmonary fibrosis more effectively than vitamin C alone?
Conclusion
Aptamin C significantly improves survival rates and reduces inflammation in pulmonary fibrosis compared to vitamin C.
Supporting Evidence
- Aptamin C-treated mice had a 50% survival rate, while all vitamin C-treated mice died.
- Inflammation was significantly reduced in the lungs of mice treated with Aptamin C compared to those treated with vitamin C.
- Aptamin C increased the expression of SVCT-1, enhancing vitamin C absorption.
Takeaway
Aptamin C helps mice with lung disease live longer and feel better by reducing inflammation.
Methodology
Mice with bleomycin-induced pulmonary fibrosis were treated with either vitamin C or Aptamin C, and their survival and inflammation levels were monitored.
Limitations
The study was conducted on animal models, and further research is needed to confirm results in humans.
Participant Demographics
Gulo (−/−) knockout mice, male, 11 weeks old.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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