IL-17A Expression in Inflammatory Arthritis
Author Information
Author(s): Moran Ellen M., Heydrich René, Ng Chin Teck, Saber Tajvur P., McCormick Jennifer, Sieper Joachim, Appel Heiner, Fearon Ursula, Veale Douglas J.
Primary Institution: Department of Rheumatology, St. Vincent's University Hospital, Dublin Academic Healthcare, Dublin, Ireland
Hypothesis
This study examines the expression of IL-17A-secreting cells within the inflamed synovium and the relationship to in vivo joint hypoxia measurements.
Conclusion
IL-17A expression is localized to several immune cell subtypes within the inflamed synovial tissue, indicating its role as a key mediator in inflammatory arthritis.
Supporting Evidence
- IL-17A expression was localized to mononuclear and polymorphonuclear cells in inflamed synovial tissue.
- The number of IL-17A-secreting PMN cells significantly correlated with sublining CD68 expression.
- Patients with low oxygen levels in the joint had significantly higher IL-17A positive mononuclear cells.
Takeaway
The study found that a protein called IL-17A is made by certain immune cells in swollen joints, which might help cause arthritis.
Methodology
IL-17A expression was quantified in synovial tissue, serum, and synovial fluid using immunohistochemistry and MSD-plex assays.
Participant Demographics
Patients with active inflammatory arthritis, including rheumatoid arthritis and psoriatic arthritis.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website