Biodegradable Polymers Induce CD54 on THP-1 Cells in Skin Sensitization Test
2011
Effects of Biodegradable Polymers on Skin Sensitization
publication
Evidence: moderate
Author Information
Author(s): Jung Yeon Suk, Kato Reiko, Tsuchiya Toshie
Primary Institution: National Institute of Health Sciences
Hypothesis
Do biodegradable polymers induce skin sensitization as measured by CD54 expression in THP-1 cells?
Conclusion
Biodegradable polymers can induce skin sensitization by increasing CD54 expression without affecting cell viability.
Supporting Evidence
- Biodegradable polymers increased CD54 expression in THP-1 cells.
- Polymers P1, P3, P5, and P6 showed high skin sensitization potential.
- Skin sensitization can be assessed without animal testing.
Takeaway
This study found that some biodegradable materials can make your skin react, and we can test this without using animals.
Methodology
The study used the human cell line activation test (h-CLAT) to assess the effects of biodegradable polymers on THP-1 cells.
Limitations
P4 could not be assessed due to causing cell death, and P2 did not increase skin sensitization.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website