XANTHURENIC ACID (XA) TREATMENT IMPROVES OVERALL HEALTH IN AGED MICE
2024
Xanthurenic Acid Treatment Improves Health in Aged Mice
publication
Evidence: moderate
Author Information
Author(s): Vyavahare Sagar, Kumar Sandeep, Gupta Sonu Kumar, Ding Kehong, Isales Carlos, Fulzele Sadanand
Primary Institution: Augusta University
Hypothesis
This study aimed to examine the levels of serum xanthurenic acid (XA) in aged mice and investigate the potential impacts of XA treatment on their overall health.
Conclusion
XA treatment in aged mice led to improved health parameters and reduced inflammation.
Supporting Evidence
- XA serum levels decrease with age.
- XA treatment decreased pro-inflammatory cytokines in serum.
- XA treated aged mice showed improved grip strength and locomotor activity.
- Musculoskeletal analyses revealed improved bone microarchitecture in XA-treated mice.
- XA treatment prevented oxidative stress and reduced senescence markers in aged mice.
Takeaway
Giving older mice a substance called xanthurenic acid helped them feel better and be stronger.
Methodology
The study measured serum xanthurenic acid levels and assessed health parameters in aged mice after XA treatment.
Participant Demographics
Aged mice were used in the study.
Digital Object Identifier (DOI)
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