Hesperidin in KMP6 Reduces Allergic Reactions by Inhibiting Mast Cell Migration
Author Information
Author(s): Jeong Hyun-Ja, Choi Youngjin, Kim Kyu-Yeob, Kim Min-Ho, Kim Hyung-Min
Primary Institution: Biochip Research Center, Hoseo University, Asan, Republic of Korea
Hypothesis
Does KMP6 and its component hesperidin inhibit SCF-induced migration of mast cells?
Conclusion
KMP6 and hesperidin significantly inhibit SCF-induced migration and inflammatory cytokine production in mast cells.
Supporting Evidence
- KMP6 and hesperidin significantly inhibited SCF-induced migration of rat peritoneal mast cells.
- The ability of SCF to enhance morphological alteration and F-actin formation was abolished by treatment with KMP6 or hesperidin.
- KMP6 and hesperidin inhibited SCF-induced p38 MAPK activation.
- SCF-induced inflammatory cytokine production was significantly inhibited by treatment with KMP6 or hesperidin.
Takeaway
This study found that a natural extract called KMP6 can help stop certain allergic reactions by preventing special cells from moving where they shouldn't.
Methodology
The study used rat peritoneal mast cells to assess the effects of KMP6 and hesperidin on SCF-induced migration and cytokine production.
Participant Demographics
Male Wistar rats weighing 200–300 g were used in the experiments.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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