Folate and Colorectal Cancer Prevention
Author Information
Author(s): Hubner R A, Houlston R S
Primary Institution: Royal Marsden Hospital
Hypothesis
Does dietary folate intake influence the risk of colorectal cancer?
Conclusion
The relationship between folate intake and colorectal cancer risk is complex, with both protective and potentially harmful effects depending on timing and dosage.
Supporting Evidence
- Thirteen case-control studies and eight cohort studies have examined the relationship between folate intake and CRC.
- A meta-analysis indicated a 25% reduction in CRC risk for subjects in the highest quintile of dietary folate intake.
- Long-term folic acid supplementation showed a significant 75% risk reduction in CRC after 15 years.
Takeaway
Eating foods with folate can help prevent cancer, but too much folate later on might actually make things worse.
Methodology
The study reviewed epidemiological data and randomized controlled trials regarding folate intake and colorectal cancer risk.
Potential Biases
Potential confounding factors in dietary assessments may affect the results.
Limitations
The evidence is suggestive but not definitive, and further studies are needed to clarify the relationship.
Participant Demographics
The study included data from various cohorts, including over 88,000 female participants in the Nurses' Health Study.
Statistical Information
P-Value
0.05
Confidence Interval
95% CI: 0.98–1.21
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website