Adverse Events from Smallpox Vaccination with Different Strains
Author Information
Author(s): Kretzschmar Mirjam, Wallinga Jacco, Teunis Peter, Xing Shuqin, Mikolajczyk Rafael
Primary Institution: Rijksinstituut voor Volksgezondheid en Milieu/National Institute for Public Health and the Environment
Hypothesis
How do different vaccinia strains affect the frequency of adverse events after smallpox vaccination?
Conclusion
Vaccination with the Lister strain leads to significantly higher rates of adverse events compared to the NYCBH strain.
Supporting Evidence
- Vaccination with the NYCBH strain leads to an average of 1.4 deaths per million vaccinations.
- Vaccination with the Lister strain leads to an average of 8.4 deaths per million vaccinations.
- The study found large heterogeneity in adverse event rates across different studies.
- Younger children are at higher risk for adverse events after vaccination.
Takeaway
Some smallpox vaccines can make people sick, and different types of vaccines can cause different amounts of sickness.
Methodology
The study conducted a systematic review and statistical analysis of historical vaccination data, focusing on adverse events related to different vaccinia strains.
Potential Biases
Different studies may have used varying methods for reporting adverse events, leading to potential biases.
Limitations
The quality of historical data varied, making it difficult to ensure reliability.
Participant Demographics
Data were collected from various countries and age groups, but specific demographics were not detailed.
Statistical Information
Confidence Interval
95% credible interval
Digital Object Identifier (DOI)
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