Development and Disease: How Susceptibility to an Emerging Pathogen Changes through Anuran Development
2011

How Development Affects Amphibian Susceptibility to Ranavirus

Sample size: 140 publication 10 minutes Evidence: high

Author Information

Author(s): Haislip Nathan A., Gray Matthew J., Hoverman Jason T., Miller Debra L.

Primary Institution: University of Tennessee

Hypothesis

Susceptibility to ranavirus would be greatest at metamorphosis.

Conclusion

The study found that four species of amphibians were most susceptible to ranavirus during larval or hatchling stages, not during metamorphosis as previously thought.

Supporting Evidence

  • Mortality and infection prevalence were significantly greater in hatchling, larval, and metamorph stages compared to embryos.
  • L. sylvaticus and S. holbrookii had the highest mortality rates.
  • Embryos were the least susceptible stage across species when exposed to ranavirus.

Takeaway

Amphibians can get sick from a virus called ranavirus, and they are more likely to get sick when they are babies or young, not just when they are changing into adults.

Methodology

The study involved exposing seven anuran species at four developmental stages to ranavirus and measuring mortality and infection prevalence.

Potential Biases

Potential bias due to low control mortality rates in some species.

Limitations

The study's results may not be generalizable to all amphibian species or environmental conditions.

Participant Demographics

Seven species of anurans were used, including Lithobates clamitans, L. pipiens, L. sylvaticus, Pseudacris feriarum, Hyla chrysoscelis, Scaphiopus holbrookii, and Anaxyrus americanus.

Statistical Information

P-Value

<0.001

Statistical Significance

p<0.001

Digital Object Identifier (DOI)

10.1371/journal.pone.0022307

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