Low Vitamin D Levels in Narcolepsy with Cataplexy
Author Information
Author(s): Carlander Bertrand, Puech-Cathala Anne Marie, Jaussent Isabelle, Scholz Sabine, Bayard Sophie, Cochen Valérie, Dauvilliers Yves
Primary Institution: National Reference Network for Narcolepsy, Department of Neurology, Hôpital Gui-de-Chauliac, CHU Montpellier, Montpellier, France
Hypothesis
Is narcolepsy with cataplexy associated with low levels of vitamin D?
Conclusion
Patients with narcolepsy with cataplexy have a higher frequency of vitamin D deficiency compared to healthy controls.
Supporting Evidence
- Vitamin D deficiency was found in 72.5% of narcolepsy patients compared to 50.9% of controls.
- The risk of narcolepsy increased with lower vitamin D levels.
- No significant correlation was found between vitamin D levels and disease severity.
Takeaway
People with narcolepsy often have low vitamin D levels, which might be important for their health.
Methodology
Serum vitamin D levels were measured in 51 narcolepsy patients and 55 matched controls.
Potential Biases
Potential bias due to lack of dietary vitamin intake data and the timing of blood sampling.
Limitations
Patients were not HLA-matched to controls, and sun exposure data was not collected.
Participant Demographics
51 narcolepsy patients (22 males, 29 females, median age 34) and 55 controls (20 males, 35 females, median age 36).
Statistical Information
P-Value
0.0039
Confidence Interval
95% CI = 1.06–12.46
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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