Gender differences in the relationship between depressive symptoms and diabetes associated with cognitive-affective symptoms
2024

Gender Differences in Depression and Diabetes

Sample size: 29619 publication 10 minutes Evidence: moderate

Author Information

Author(s): Meshkat Shakila, Tassone Vanessa K., Dunnett Sarah, Pang Hilary, Wu Michelle, Boparai Josheil K., Jung Hyejung, Lou Wendy, Bhat Venkat

Primary Institution: St. Michael's Hospital, Toronto, Canada

Hypothesis

Individuals with known prediabetes and diabetes would have statistically significantly higher odds of having depressive symptoms than non-diabetic individuals, with greater effects in females than in males.

Conclusion

Diabetes was associated with higher cognitive-affective symptom scores in females than in males.

Supporting Evidence

  • 28% of individuals with diabetes also suffer from a depressive disorder.
  • Females with diabetes had higher mean total depressive symptom scores than males with diabetes.
  • Statistically significant diabetes-gender interactions were found in the cognitive-affective symptom cluster model.
  • Individuals with diabetes had statistically significantly higher odds of having depressive symptoms compared to those without diabetes.

Takeaway

This study found that women with diabetes tend to feel sadder than men with diabetes, and diabetes makes women feel worse than it does men.

Methodology

Cross-sectional analyses were conducted on participants from the National Health and Nutrition Examination Survey, using logistic and linear regression to analyze relationships between depressive symptoms and diabetes.

Potential Biases

Self-reporting may introduce bias, and the cross-sectional design limits causal inferences.

Limitations

The study relied on self-reported diabetes status and used a self-report scale for depressive symptoms, which may not capture all cases of major depressive disorder.

Participant Demographics

The sample included 29,619 participants, with a mean age of 47.64 years, and 51.32% were female.

Statistical Information

P-Value

P<0.001

Confidence Interval

CI: 0.10, 0.36

Statistical Significance

p<0.05

Digital Object Identifier (DOI)

10.1192/bjo.2024.764

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