Gemcitabine and Cisplatin for Lung Cancer Treatment
Author Information
Author(s): Yang C H, Tsai C M, Wang L S, Lee Y C, Chang C J, Lui L T, Yen S H, Hsu C, Cheng A L, Liu M Y, Chiang S C, Chen Y M, Luh K T, Huang M H, Yang P-C, Perng R-P
Primary Institution: National Taiwan University Hospital
Hypothesis
The study tests the feasibility of using gemcitabine and cisplatin as induction treatment for stage III non-small cell lung cancer patients.
Conclusion
Three cycles of gemcitabine and cisplatin are effective as induction treatment before surgery for locally advanced non-small cell lung cancer patients.
Supporting Evidence
- Two patients had complete response and 31 patients had partial response after induction chemotherapy.
- Thirty-six patients (69%) were operable after treatment.
- Eighteen patients (35%) had their tumours completely resected.
Takeaway
Doctors used two medicines, gemcitabine and cisplatin, to help patients with a type of lung cancer before surgery, and it worked well for many of them.
Methodology
Patients received three cycles of gemcitabine and cisplatin before evaluation for operability, followed by surgery or chemoradiotherapy.
Limitations
The study had a small sample size and included only specific patient demographics.
Participant Demographics
Most patients were men with squamous cell carcinoma; 90% had N2 or N3 disease.
Statistical Information
Confidence Interval
95% confidence interval 50.4–76.6% for response rate.
Digital Object Identifier (DOI)
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