Dual-Drug Suspensions: Size and Stability Insights
Author Information
Author(s): Zulbeari Nadina, Hansen Signe Malig, Holm René, Lopalco Antonio
Primary Institution: Department of Physics, Chemistry, and Pharmacy, University of Southern Denmark
Hypothesis
What are the effects of different stabilizers on the physical stability of dual-drug suspensions containing indomethacin and naproxen?
Conclusion
The study provides insights into the preparation and physical stability of dual-drug suspensions containing indomethacin and naproxen.
Supporting Evidence
- The combination of indomethacin and naproxen resulted in smaller drug particle sizes compared to individual suspensions.
- At least one model compound needed to be sufficiently stabilized to achieve physical stability over 28 days.
- Dual-drug suspensions showed a synergistic stabilization effect when both compounds were present.
Takeaway
This study looks at how to mix two medicines, indomethacin and naproxen, in a way that keeps them stable for a long time. It found that using the right helpers (stabilizers) can make the mixture work better.
Methodology
The study prepared dual-drug nano- and microsuspensions using dual centrifugation and assessed their physical stability by measuring particle sizes over 28 days at elevated temperatures.
Limitations
The study did not cover the chemical stability of the prepared suspensions.
Digital Object Identifier (DOI)
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