Characteristics of Colorectal Cancer in I1307K APC Mutation Carriers
Author Information
Author(s): Figer A, Shtoyerman-Chen R, Tamir A, Geva R, Irmin L, Flex D, Theodor L, Sulkes A, Sadetzki S, Bar-Meir S, Friedman E
Primary Institution: Institute of Oncology Rabin Medical Center, Beilinson Campus, Petach-Tikvah
Hypothesis
The phenotype of colorectal cancer in I1307K APC mutation carriers differs from that in sporadic cases.
Conclusion
Colorectal tumors in I1307K APC mutation carriers are less likely to be located in the right colon and are more advanced compared to those in non-carriers.
Supporting Evidence
- 28 mutation carriers (9.1%) were detected among the 307 patients.
- Tumors in mutation carriers were less likely to be located in the right colon compared to non-carriers.
- 50% of mutation carriers had advanced disease stage (Dukes C) compared to 19.5% of non-carriers.
Takeaway
People with a specific gene mutation have different types of colon cancer compared to those without the mutation.
Methodology
Analyzed 307 unselected Israeli patients with colorectal cancer for the I1307K mutation.
Limitations
The study was conducted in a single medical center, which may limit the generalizability of the findings.
Participant Demographics
307 Israeli patients with colorectal cancer, including 28 mutation carriers.
Statistical Information
P-Value
P<0.01; P=0.02
Statistical Significance
p<0.01
Digital Object Identifier (DOI)
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