Evolutionary Dynamics of Eukaryotic Selenoproteomes
Author Information
Author(s): Lobanov Alexey V, Fomenko Dmitri E, Zhang Yan, Sengupta Aniruddha, Hatfield Dolph L, Gladyshev Vadim N
Primary Institution: Department of Biochemistry, University of Nebraska, Lincoln, NE, USA; Section on the Molecular Biology of Selenium, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
Hypothesis
Aquatic organisms may have larger selenoproteomes compared to terrestrial organisms due to environmental factors.
Conclusion
The study suggests that aquatic organisms retain and sometimes expand their selenoproteomes, while terrestrial organisms often reduce or lose them.
Supporting Evidence
- Distinct selenoprotein patterns were verified by metabolic labeling.
- More than half of the selenoprotein families were shared by unicellular eukaryotes and mammals.
- Comparative analyses revealed that aquatic organisms generally have large selenoproteomes.
Takeaway
This study found that sea creatures have more special proteins that use selenium than land animals, likely because of their watery homes.
Methodology
In silico and metabolic labeling studies were conducted to analyze selenoproteomes of various eukaryotes.
Potential Biases
Potential bias in the selection of organisms analyzed for selenoprotein content.
Limitations
The study may not account for all environmental factors influencing selenoproteome size.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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