‘SIRT8’ expressed in thyroid cancer is actually SIRT7
2002
SIRT8 in Thyroid Cancer is Actually SIRT7
Commentary
Author Information
Author(s): Frye R
Primary Institution: Pittsburgh VA Med Center, Pathology (132L-U), University Drive C, Pittsburgh, Pennsylvania, PA 15240, USA
Conclusion
The supposed novel gene SIRT8 is actually derived from the previously characterized SIRT7 sequence.
Supporting Evidence
- The cDNA claimed to be a novel gene is actually derived from the SIRT7 sequence.
- The supposed novel cDNA contains a sequence from the cloning vector.
- The amino-acid sequence thought to diverge from SIRT7 is likely due to sequencing errors.
- The claim of homology with telomerase proteins is unfounded.
Takeaway
Some scientists thought they found a new gene in thyroid cancer, but it turns out it was just a mistake and is actually an old gene.
Limitations
The errors in the original study were not identified by the authors or the editorial review process.
Digital Object Identifier (DOI)
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