Impact of Statins and Antihyperglycemics on Kidney Disease in Diabetic Patients
Author Information
Author(s): A. A. Jairoun, Ping Chong Chee, Ibrahim Baharudin, Al Jawamis Dina Farhan, Al Jaberi Asma Khaled, Dawoud Tasnim, Mohammed Khuloud Jamal, El-Dahiyat Faris, Shahwan Moyad
Primary Institution: Tawam Hospital, Al Ain, United Arab Emirates
Hypothesis
What is the effect of statin and antihyperglycemic interventions on chronic kidney disease progression in individuals with type 2 diabetes mellitus?
Conclusion
The study found that high-intensity statin users are more likely to develop chronic kidney disease stages 3-5 compared to low/moderate users and non-users, while Biguanides were associated with a reduced risk of progression.
Supporting Evidence
- 388 subjects developed CKD stages 3-5 over an average monitoring duration of 11.7 years.
- The cumulative incidence of CKD stages 3-5 was 38.7%.
- High intensity statin users had a higher incidence of CKD compared to low/moderate users.
- Biguanides were associated with a decreased probability of CKD progression.
- Insulin users demonstrated a heightened risk of CKD progression.
Takeaway
This study looked at how certain medications affect kidney health in people with diabetes. It found that stronger cholesterol medications might make kidney problems worse, while another type of diabetes medicine could help protect the kidneys.
Methodology
This was a single-center retrospective cohort study based on electronic medical records of UAE populations with diabetes mellitus, registered at outpatient clinics at Tawam Hospital between January 2011 and December 2021.
Potential Biases
Selection bias may be present due to the retrospective design and reliance on electronic medical records from a single location.
Limitations
The study's sample size was smaller than initially estimated, which may affect the robustness and generalizability of the findings.
Participant Demographics
The mean age of participants was 70.6 years, with 60% female and 40% male.
Statistical Information
P-Value
0.047
Confidence Interval
95% CI 11.4, 11.9 years
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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