Encapsulation of Naproxen in Lipid-Based Matrix Microspheres
Author Information
Author(s): Bhoyar PK, Morani DO, Biyani DM, Umekar MJ, Mahure JG, Amgaonkar YM
Primary Institution: S.K.B. College of Pharmacy, New Kamptee, Nagpur, Maharashtra, India
Hypothesis
The study aimed to microencapsulate naproxen to provide controlled release and minimize local side effects.
Conclusion
The study successfully developed lipid microspheres of naproxen that showed controlled release and high entrapment efficiency.
Supporting Evidence
- The drug entrapment efficiency ranged from 60 to 90% w/w.
- In vitro drug release studies showed 50-65% drug release in 24 hours.
- The microspheres were characterized for size and morphology using SEM.
- The Korsmeyer-Peppas model best described the drug release mechanism.
Takeaway
The researchers made tiny balls that hold a medicine called naproxen, which helps reduce pain, so it can be released slowly in the body without causing stomach problems.
Methodology
Naproxen microspheres were prepared using a modified melt dispersion technique, and their size, entrapment efficiency, and in vitro release were evaluated.
Digital Object Identifier (DOI)
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