APOA5 Gene Variants and Triglyceride Levels in Indian Population
Author Information
Author(s): Chandak Giriraj R, Ward Kirsten J, Yajnik Chittaranjan S, Pandit Anand N, Bavdekar Ashish, Joglekar Charu V, Fall Caroline HD, Mohankrishna P, Wilkin Terence J, Metcalf Bradley S, Weedon Michael N, Frayling Timothy M, Hattersley Andrew T
Primary Institution: Centre for Cellular and Molecular Biology, Hyderabad, India
Hypothesis
Do the APOA5 gene variants -1131T>C and S19W show similar associations with lipid parameters in the Indian population as seen in Caucasians?
Conclusion
The study confirms that APOA5 variants are associated with triglyceride levels in both Asian Indians and Caucasians, with the -1131C allele being more prevalent in Pune Indians.
Supporting Evidence
- The -1131C allele was found in 20% of Pune Indians compared to 4% in UK whites.
- The presence of -1131C allele was associated with a 19% increase in triglyceride concentrations.
- The study is the first to investigate APOA5 variants in Asian Indians residing in India.
Takeaway
This study looked at how certain gene changes affect fat levels in people from India and found that one gene change is more common in them than in people from Europe.
Methodology
Genotyping of 557 Indian adults and 237 UK white adults for APOA5 variants and analysis of their association with lipid parameters using general linear analysis.
Limitations
The study may not be generalizable to all South Asian populations as it focuses on a specific cohort from Pune.
Participant Demographics
557 Pune Indian adults and 237 UK white adults, with a median age of 36 years for Pune Indians.
Statistical Information
P-Value
p = 0.00001 for -1131C allele prevalence
Confidence Interval
95% CI, 0.12–0.39 for triglyceride increase associated with -1131C allele
Statistical Significance
p<0.00001
Digital Object Identifier (DOI)
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