Atorvastatin-Induced Liver Injury with Rhabdomyolysis
Author Information
Author(s): Harjit Singh MD, MBA, Adam Khalaf MD, Bryce F. Kunkle MD, Sherry Gholami MD, James H. Lewis MD, FACG, Amol S. Rangnekar MD
Primary Institution: MedStar Georgetown University Hospital
Hypothesis
Can atorvastatin cause significant liver injury and rhabdomyolysis upon rechallenge?
Conclusion
The case highlights the risk of severe liver injury and rhabdomyolysis associated with atorvastatin, especially after a positive rechallenge.
Supporting Evidence
- This is the first reported case of concurrent drug-induced liver injury and rhabdomyolysis after a positive rechallenge with atorvastatin.
- Atorvastatin was found to be a highly probable cause of the liver injury based on causality assessment methods.
- The patient experienced significant liver enzyme elevations and rhabdomyolysis after rechallenging with atorvastatin.
Takeaway
A woman got very sick from a medicine called atorvastatin, which hurt her liver and muscles, and it got worse when she took it again.
Methodology
The case report details the clinical presentation, laboratory findings, and treatment of a patient who experienced liver injury and rhabdomyolysis after taking atorvastatin.
Limitations
The findings are based on a single case report, limiting generalizability.
Participant Demographics
A 56-year-old woman with a history of hypertension and ischemic cerebrovascular accident.
Digital Object Identifier (DOI)
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