Prevalence of MBL Producing Pseudomonas aeruginosa and Acinetobacter in ICUs
Author Information
Author(s): De Anuradha S. Kumar, Simit H. Baveja, Sujata M.
Primary Institution: L.T.M. Medical College, Mumbai, India
Hypothesis
The study aims to determine the prevalence of metallo-β-lactamase producing Pseudomonas aeruginosa and Acinetobacter species in intensive care areas.
Conclusion
The prevalence of metallo-β-lactamase producers was found to be 33.33%, with a high mortality rate of 46.15% among MBL-positive patients.
Supporting Evidence
- 33.33% of the tested isolates were found to produce metallo-β-lactamases.
- All MBL-positive isolates were multidrug resistant.
- The mortality rate among MBL-positive patients was 46.15%.
- Risk factors for MBL acquisition included prolonged hospital stay and previous antibiotic use.
Takeaway
Doctors found that a third of the bacteria causing infections in ICU patients were very hard to treat, and many of those patients died.
Methodology
The study tested 39 non-duplicate isolates for MBL production using modified-EDTA disc synergy and double disc synergy tests.
Limitations
The study was limited to a single tertiary care hospital and may not represent broader populations.
Participant Demographics
The study included 24 adults and 15 children from intensive care units.
Digital Object Identifier (DOI)
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